Synthesis of 2- and 4-hydroxymethyl Loratadine, usual impurities in Loratadine syrup formulations
نویسندگان
چکیده
منابع مشابه
LC determination of loratadine and related impurities.
Loratadine, an antihistamine, could include in its raw material seven impurities that ought to be separated identified and quantified for drug development and quality control. A HPLC method employing a SymmetryShield RP8 column has been developed and validated for loratadine and related compounds measurement, the last ones under the 0.1% level. The mobile phase consisted of methanol-buffer A (6...
متن کاملCapillary electrophoresis determination of loratadine and related impurities.
While HPLC has traditionally been the method of choice for purity determination of pharmaceutical substances, capillary electrophoresis (CE) offers a different selectivity and hence it is a complementary technique to HPLC. Loratadine, an antihistamine, could include in its raw material seven impurities that ought to be separated, identified and quantified for drug development and quality contro...
متن کاملSynthesis of 3-hydroxy desloratadine, the hydroxyl metabolite of loratadine
The structure of a major active metabolite of the nonsedating antihistamine loratadine was confirmed by synthesis. The metabolite 3 was prepared from 3-methyl pyridine in twelve steps.
متن کاملA New Validated Liquid Chromatographic Method for the Determination of Loratadine and its Impurities
An improved gradient, reversed-phase liquid chromatographic (RP-LC) method was developed and subsequently validated for the determination of Loratadine and its impurities/degradation products in pharmaceutical drug substance. Separation was achieved with Inertsil ODS-3V, 250 × 4.6 mm, 5μ column with gradient elution at a flow rate of 1.0 mL min(-1). UV detection was performed at 220 nm. The des...
متن کاملFixed drug eruption due to loratadine.
We present the clinical case of a 8-years-old boy suffering a fixed drug reaction attributed to the oral intake of loratadine. He is an atopic child with perennial rhinitis and asthma and marked hypersensitivity to the house-dust mite Dermatophagoides pteronyssinus who is receiving inhaled corticosteroids and b2-agonists ad libitum plus specific immunotherapy with the mite. When the boy receive...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arkivoc
سال: 2005
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0006.920